Colorado vs. USC odds, spread, line: 2023 college football picks, Deion Sanders predictions by proven model

 

SportsLine's model just revealed its CFB picks for the USC Trojans vs. Colorado Buffaloes on Saturday as Deion Sanders and the Buffaloes look to bounce back from their first loss of the season.

No. 8 USC will go on the road for the second week in a row when it travels to Colorado on Saturday. The Trojans played their first road game of the season last week, improving to 4-0 with a 42-28 win at Arizona State. Colorado opened the year with three straight wins, but came up well short in a 42-6 loss at then-No. 10 Oregon last week. The Buffaloes will be without two-way star Travis Hunter (lacerated liver) again on Saturday. 

Kickoff is scheduled for noon ET. The Trojans are 22.5-point favorites in the latest USC vs. Colorado odds, while the over/under for total points scored is 73. Before making any Colorado vs. USC picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed the model has seen huge returns.

Now, the model has set its sights on USC vs. Colorado and just revealed its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and trends for Colorado vs. USC:

Why USC can cover

Caleb Williams & Co. have a plus matchup going up against the Colorado pass defense. Led by Williams, the Trojans rank third in the country in passing offense (377.2 yards per game). They'll face a Buffaloes defense that allows 269.2 passing yards per game, which ranks 111th in the country. Last week Colorado was torched for 217 passing yards and three touchdowns in just the first half by Oregon.

In addition, the Buffaloes have had difficulty protecting the quarterback this season. With an offensive line featuring multiple transfers and a true freshman, Colorado gives up 5.75 sacks per game this season. That is the second most among all 130 FBS programs, behind only Old Dominion (6.50). Colorado two-way star Travis Hunter will also miss this game as he continues to recover from a lacerated liver. See which team to pick here.

Why Colorado can cover

Colorado's performance against Oregon was disastrous, but the Buffaloes covered the spread in outright wins over then-No. 17 TCU and Nebraska during the first two weeks of the season. While USC's offense has been elite, the Trojans have been mediocre on the defensive side of the ball. They allowed 28 points to both San Jose State and Arizona State, failing to cover the spread in either of those games.

The Buffaloes have an offense that can take advantage, scoring more than 35 points in each of their first three outings. Junior quarterback Shedeur Sanders has racked up 1,410 passing yards, 11 touchdowns and one interception, while running back Dylan Edwards is averaging 5.6 yards per carry. USC has not been meeting market expectations since the end of last season, covering the spread just two times in its last six games. See which team to pick here.

How to make USC vs. Colorado picks

SportsLine's model is leaning Under the point total. The model also says one side of the spread hits in well over 50% of simulations. You can see the model's picks at SportsLine. 

Did Colorado win against USC?

The result was all too familiar, though — another win for Southern California. Williams threw for 403 yards and tied a career high with six touchdown passes as the eighth-ranked Trojans held off the Buffaloes 48-41 on Saturday after racing out to a big lead.

Has Colorado University ever won a championship?

Bill McCartney is the most famous head coach, leading Colorado to its only national championship in 1990. Current head coach Deion Sanders was approved by the university's board of regents in December 2022. Beginning competitive play in 1890, Colorado has enjoyed much success through its history.

Who is Omarion Miller?

He was a star in both football and basketball and was named 2022 Male Athlete of the Year by Shreveport Times. He initially committed to LSU, but flipped to Nebraska in July 2022, and finally signed with Colorado after Deion Sanders took over as the Buffaloes' head coach.

Who has won more USC or UCLA?

USC has won 17 championships outright, shared eight and gone to the Rose Bowl or BCS bowl 21 times. UCLA has won six championships outright, shared five and gone to the Rose Bowl eight times. The schools have thrice shared the championship.

Who wins USC or Stanford?

LOS ANGELES (AP) — Caleb Williams passed for 281 yards and three touchdowns and ran for another score while playing only the first half, Zachariah Branch returned a punt 75 yards for a TD, and No. 6 USC Football routed Stanford 56-10 Saturday night in this decades-old rivalry's final chapter for the foreseeable future.

Who wins USC or Stanford?

LOS ANGELES (AP) — Caleb Williams passed for 281 yards and three touchdowns and ran for another score while playing only the first half, Zachariah Branch returned a punt 75 yards for a TD, and No. 6 USC Football routed Stanford 56-10 Saturday night in this decades-old rivalry's final chapter for the foreseeable future.